- Major depressive disorder (MDD)
$49 per month
- Major depressive disorder in adults and adolescents at least 12 years old
- Anxiety in adults
$49 per month
vortioxetine
escitalopram
Most common
Most serious
Most common
More serious
You should not use Trintellix if you:
Talk to your physician before taking Trintellix if you:
You should not use Lexapro if you:
You should talk to your doctor before using Lexapro if you:
5 to 20 mg once a day maintenance
10 or 20 mg once daily
30, 20 mg Trintellix tablets will cost around $660.
30, 20mg Lexapro tablets will cost around $100
Trintellix and Lexapro are brand names for prescription drugs used for the treatment of mental health disorders such as depression. Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.
Trintellix (previously known as Brintellix) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Takeda. It is an antidepressant drug prescribed to adults to treat major depressive disorder (MMD). If you have MDD, your doctor may prescribe Trintellix to you, in addition to recommending other treatments. Trintellix works by increasing levels of a natural substance that regulates your brain activity called serotonin. This can reduce the severity of depressive episodes and help keep them at bay. You take Trintellix as a tablet you swallow.
The active ingredient in Trintellix is called vortioxetine. It’s a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). When you swallow a Trintellix tablet, it releases vortioxetine into your bloodstream. Vortioxetine is then carried in your blood to your brain, where it slows down how quickly your brain cells reabsorb a substance called serotonin.
Serotonin is a neurotransmitter that helps regulate your brain function, particularly areas of your brain involved in mood, learning, and memory. Your brain cells reabsorb excess serotonin, but vortioxetine slows down how quickly this happens, causing serotonin levels to rise. This can rebalance your serotonin levels, Research has shown this can help to reduce depressive symptoms.
Trintellix is available as immediate-release tablets, in the following doses: 5 mg, 10 mg, and 20 mg. The recommended starting dose is 10 mg once daily with or without meals and increased as tolerated. Do not discontinue Trintellix treatment abruptly. Reduce doses of 15 mg/day or 20 mg/day to 10 mg/day for one week before complete discontinuation.
Lexapro (escitalopram oxalate) is an FDA (U.S. Food and Drug Administration) approved antidepressant medication manufactured by Forest Laboratories. Lexapro is a selective serotonin reuptake inhibitor (SSRI) used for:
Lexapro is not recommended for use in pediatric patients less than 12 years of age, due to an increased risk of suicidal thoughts and behavior in children, adolescents, and young adults.
Lexapro is available in tablet or oral solution form, in the following doses: 5 mg, 10 mg, 20 mg, and 1 mg per mL. As with Trintellix, when discontinuing Lexapro, withdrawal symptoms such as agitation may occur. Taper off the drug slowly and do not stop abruptly.
Always speak with a healthcare professional for medical advice about any changes to your dose so they can monitor and evaluate your condition.
The most common side effects of Trintellix in clinical trials compared to placebo include:
More serious side effects of Trintellix include:
The most common side effects of Lexapro in clinical trials include:
More serious side effects of Lexapro include
These aren’t all the side effects Trintellix or Lexapro can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or a pharmacist.
Trintellix can interact with other medications. These include:
Lexapro can interact with other medications. These include:
Trintellix and Lexapro can interact with other medications. This can change how Trintellix and Lexapro and other medications work and can make side effects more likely. Tell your prescribing physician about all your drugs, including vitamins and dietary supplements.
You should not use Trintellix if you:
Talk to your doctor before using Trintellix if you:
You should not use Lexapro if you:
Talk to your doctor before using Lexapro if you:
If you have any concerns about Trintellix or Lexapro side effects, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.