- Major depressive disorder (MDD)
$49 per month
- Major depressive disorder (MDD)
$49 per month
Drug facts and comparison
You should not use Trintellix if you:
Talk to your physician before taking Trintellix if you:
You should not use Viibryd if you:
Talk to your physician before taking Viibryd if you:
5 to 20 mg once a day maintenance
40 mg once daily maintenance
30, 20 mg Trintellix tablets will cost around $660.
30 Viibryd tablets will cost around $300.
Trintellix (vortioxetine) and Viibryd (vilazodone) are selective serotonin reuptake inhibitor (SSRI) antidepressants. Both medicines are prescription drugs approved by the United States Food and Drug Administration (FDA) to treat major depressive disorder in adults only. Let’s take a look at the similarities and differences between them.
Viibryd is the brand name of an FDA (Food and Drug Administration) approved antidepressant medication for adults containing the active ingredient vilazodone. Viibryd is classed as a selective serotonin reuptake inhibitor (SSRI) and a partial serotonin 5-HT1A receptor agonist.
It is thought to work by correcting the imbalance of serotonin, a neurotransmitter in your brain. Low levels of serotonin may be linked to symptoms of depression. Due to Viibryd’s ability to activate 5-HT1A receptors, it can also decrease blood pressure and increase calm behavior and have other effects.
Viibryd is used to treat:
Trintellix is a brand name antidepressant originally called Brintellix prescribed to adults to treat:
It’s a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). If you have MDD, your doctor may prescribe Trintellix to you, in addition to recommending other treatments. Trintellix works by increasing levels of a natural substance that regulates your brain activity called serotonin. This can reduce the severity of depressive episodes and help keep them at bay. You take Trintellix as an oral tablet that you swallow.
The active ingredient in Trintellix is called vortioxetine. The active ingredient in Viibryd is called vilazodone. Both these drugs are a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). When you swallow a Trintellix or Viibryd tablet, it releases vortioxetine or vilazodone into your bloodstream. Vortioxetine or vilazodone is then carried in your blood to your brain, where it slows down how quickly your brain cells reabsorb a substance called serotonin.
Serotonin is a neurotransmitter that helps regulate your brain function, particularly areas of your brain involved in mood, learning, and memory. Your brain cells reabsorb excess serotonin, but vortioxetine and vilazodone slow down how quickly this happens, causing serotonin levels to rise. This can rebalance your serotonin levels. Research has shown this can help to reduce the symptoms of depression.
Your body uses serotonin in many different ways: to regulate mood, control bowel movements, control nausea, and regulate sleeping and waking, and is also involved in blood clotting, bone health, and mental health. This neurotransmitter plays an important role in the body.
Trintellix is available in three different strength immediate-release, film-coated tablets:
Your doctor will advise you on your dosing regime. Triltellix can be taken with or without food. Each individual will be different and the dose will change from person to person. Some patients may begin with the 5 mg dose, others may take the higher dose. Always follow your doctor’s instructions and seek medical advice if you are unsure about dosing. The medication guide for Trintellix will be provided by your pharmacist before you start taking Trintellix.
Never stop your medication abruptly without consulting your doctor as withdrawal symptoms are possible. In clinical trials, some patients experienced discontinuation symptoms such as headache, muscle tension, mood swings, sudden outbursts of anger, dizziness, and a runny nose. This may occur in the first week of sudden discontinuation of Trintellix 15 mg daily or 20 mg daily.
Viibryd is available in three different strengths of film-coated tablets:
Start with an initial dosage of 10 mg once daily for 7 days, followed by 20 mg once daily. The dose may be increased up to 40 mg once daily after a minimum of 7 days between dosage increases. Viibryd is to be taken with food. Taking Viibryd on an empty stomach could result in the drug not working as well. The drug absorbs better when taken with food. Your doctor will advise you on your dosing regime. Each individual will be different and the dose will change from person to person.
The most commonly observed adverse side effects with Trintellix are:
The most commonly seen adverse side effects of Viibryd are:
Common side effects observed with both Trintellix and Viibryd are:
Sometimes, Trintellix and Viibryd can cause more serious side effects. These include:
To minimize drug interactions and worsening of possible side effects you must inform your health care professional of other medical conditions you are taking prescription drugs to treat, over-the-counter medications such as cough suppressant dextromethorphan, or supplements such as St. John’s Wort. If you are breastfeeding and taking Trintellix, talk with your doctor about the potential risks and benefits. This article is not medical advice therefore always speak to your doctor about your health conditions.
You are encouraged to report the negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Trintellix and Viibryd can interact with other medications, including:
Drug interactions with Viibryd only
Antidepressants can increase the risk of suicidal thoughts and suicide in children and young adults, particularly during the first few months of treatment. Trintellix and Viibryd are not for use in children, but young adults taking them should be monitored for signs of sudden changes in behavior, mood, thoughts, or feelings. Seek urgent medical attention if you, or someone you care for, feels they are at risk of suicide.
Don’t take Trintellix or Viibryd if you:
Talk to your doctor before taking Trintellix or Viibryd if you:
Like other serotonergic antidepressants, Trintellix and Viibryd carry a boxed warning due to the risk for suicidal thoughts and actions. In studies, Trintellix and Viibryd were shown to increase suicidal thoughts and actions in children, adolescents, and young adults (up to 24 years old). Trintellix is not approved for use in pediatric patients.
The FDA requires all antidepressant-treated patients to be monitored for clinical worsening and the emergence of suicidal thoughts or behaviors. It is very important that family members monitor their loved one’s behavior closely and any change in mood which might indicate an emerging problem should immediately trigger concern about stopping medication therapy.
A boxed warning is the strongest warning that the FDA requires. These warnings alert doctors and patients about drug effects that may be dangerous.
Serotonin syndrome occurs when serotonin levels in the body are dangerously high. This can happen when Trintellix or Viibryd are taken alone or with other antidepressants such as sertraline, citalopram, paroxetine, fluoxetine, and escitalopram, attention deficit hyperactivity disorder (ADHD) drugs, St. John’s wort, and others.
Symptoms of serotonin syndrome can include:
Symptoms of serotonin syndrome can be severe and sometimes even life-threatening. If you experience any of the above symptoms while taking Trintellix or Viibryd then please stop immediately.
Trintellix did not significantly impact weight in short-term studies and during a 6-month phase of a long-term study of patients who responded to Trintellix when compared to patients taking a sugar pill. Some reports of weight gain have been received since product approval.
Like other serotonergic antidepressants, Trintellix and Viibryd may cause sexual side effects during treatment. In clinical trials for Viibryd, up to 4% of people taking Viibryd reported sexual side effects compared to 1% of people who took a placebo.
In 6 to 8-week clinical studies with Trintellix the overall incidence in sexual dysfunction was as follows: in male patients the overall incidence was 3%, 4%, 4%, 5% in Trintellix 5mg/day, 10 mg/day, 15 mg/day, 20 mg/day, respectively, compared to 2% in placebo. In female patients, the overall incidence was <1%, 1%, <2%, 2% in Trintellix 5 mg/day, 10 mg/day, 15 mg/day, 20 mg/day, respectively, compared to <1% in placebo. These results were from voluntary reports of sexual side effects of antidepressants which are known to be underreported in part because patients may be reluctant to discuss them.
Male sexual dysfunction symptoms include:
Female sexual dysfunction symptoms:
Talk to your healthcare provider if you develop any changes in your sexual function or if you have any questions or concerns about sexual problems during treatment. Other alternatives are available.
When Trintellix or Viibryd are used with other medications that increase the risk of bleeding such as nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin, or warfarin there is a serious bleeding risk. Nose bleeds, bleeding in the stomach, or bleeding in the brain have the potential to occur.
Symptoms of serious bleeding can include:
You should be informed about the risk of bleeding associated with using Viibryd and antiplatelet agents or anticoagulants together. For patients taking warfarin, carefully monitor coagulation levels when initiating, titrating, or discontinuing Trintellix or Viibryd.
Certain people and people older than 65 years of age, or those taking a diuretic medication, are more likely to have this side effect. Trintellix and Viibryd can cause low sodium levels.
Symptoms of low sodium can include:
Your doctor may weigh the risks and benefits when prescribing Trintellix and Viibryd during pregnancy. Using Trintellix or Viibryd during the third trimester of pregnancy can increase the risk for persistent high blood pressure in the pulmonary artery and withdrawal in the newborn.
If you are pregnant or plan on becoming pregnant, it is best to speak with your healthcare provider before starting a medication.
Talk to your healthcare provider if you are breastfeeding or planning to breastfeed. It is unknown if this drug passes into breast milk.
Trintellix’s and Viibryd’s prescribing information does not list alcohol as a contraindication or warning but is strongly discouraged by healthcare professionals. Trintellix and Viibryd can worsen the effects of alcohol, while alcohol can worsen the side effects of Trintellix and Viibryd. When you have depression, you have an increased risk of developing a substance use disorder. Therefore mixing antidepressants with alcohol can lead to alcohol abuse, increasing the potential to become alcohol dependent. If you drink and develop an addiction to alcohol, it will become more difficult for you to control your symptoms of depression and get your alcohol consumption under control. You may need more frequent and long-term treatment if you have both an alcohol use disorder and depression.
The combination of alcohol and antidepressants can be very challenging if someone is drinking, binge drinking, heavy drinking, or has an alcohol use disorder prior to taking antidepressants. Furthermore, if someone decides to stop taking drugs for depression and starts drinking alcohol for symptom management instead, they can worsen their symptoms of depression, in some cases leading to suicidal thoughts.
There are several classes of antidepressants:
Trintellix and Viibryd both act like SSRI antidepressant prescription drugs. SSRIs are the most widely prescribed type of antidepressant altering serotonin levels. They are usually prescribed over other antidepressants, as they tend to cause fewer side effects.
Examples of SSRIs:
Trintellix and Viibryd act like SSRIs, they also work in other ways on serotonin receptors, which are not completely understood. Viibryd is officially categorized as an SSRI and a 5-HT1A partial agonist. Trintellix is classed as an SSRI and acts as an antagonist, agonist, and partial agonist of multiple serotonin receptors. Due to their activity, they are also known as atypical antidepressants.
Atypical antidepressants don’t fit into other classes of antidepressants, but target different neurotransmitters such as dopamine to change the brain chemistry and regulate mood.
Examples of Atypical antidepressants:
SNRIs are similar to SSRIs. They were designed to be a more effective antidepressant than SSRIs but it seems that some people respond better to SSRIs, while others respond better to SNRIs. SNRI antidepressants work on altering serotonin and norepinephrine neurotransmitters.
Examples of SNRIs:
TCAs are the traditional type of antidepressant. They are no longer usually recommended as the first treatment for depression because they can be more dangerous if an overdose is taken. They also cause more unpleasant side effects than SSRIs and SNRIs.
TCAs respond better to severe depression and can be used for other mental health conditions, such as OCD and bipolar disorder. Amitriptyline can also be used to treat chronic pain.
Examples of TCAs:
MAOIs are an older type of antidepressant that is rarely used nowadays. They can cause potentially serious side effects so should be prescribed with caution.
Examples of MAOIs: