- Major depressive disorder (MDD)
$49 per month
- Major depressive disorder
- Obsessive-compulsive disorder
- Panic disorder
- Post-traumatic stress disorder
- Social anxiety disorder
- Premenstrual dysphoric disorder
$49 per month
vortioxetine
sertraline
Most common
Most serious
Most common
More serious
You should not use Trintellix if you:
Talk to your physician before taking Trintellix if you:
You should not use Zoloft if you:
Talk to your physician before taking Zoloft if you:
5 to 20 mg once a day maintenance
100 to 200 mg once a day
30, 20 mg Trintellix tablets will cost around $660.
30, 50 mg Zoloft tablets will cost around $140
Trintellix and Zoloft are brand names for prescription drugs used to treat depression and other mental health disorders. Here we will explain how they work, their similarities and differences, their side effects, and more. This should provide you with the basics to better understand your options.
Trintellix (previously known as Brintellix) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Takeda. It is an antidepressant drug prescribed to adults to treat major depressive disorder (MDD). If you have MDD, your doctor may prescribe Trintellix to you, in addition to recommending other treatments. Trintellix works by increasing levels of a natural substance that regulates your brain activity called serotonin. This can reduce the severity of depressive episodes and help keep them at bay. You take Trintellix as a tablet you swallow.
The active ingredient in Trintellix is called vortioxetine. It’s a type of antidepressant called a selective serotonin reuptake inhibitor (SSRI). When you swallow a Trintellix tablet, it releases vortioxetine into your bloodstream. Vortioxetine is then carried in your blood to your brain, where it slows down how quickly your brain cells reabsorb a substance called serotonin. Unlike other antidepressants, Trintellix also binds to and blocks certain types of serotonin receptors in the brain.
Serotonin is a neurotransmitter that helps regulate your brain function, particularly areas of your brain involved in mood, learning, and memory. Your brain cells reabsorb excess serotonin, but vortioxetine slows down how quickly this happens, causing serotonin levels to rise. This can rebalance your serotonin levels, Research has shown this can help to reduce depressive symptoms.
Trintellix is available as immediate-release tablets, in the following doses: 5 mg, 10 mg, and 20 mg. The recommended starting dose is 10 mg once daily with or without meals and increased as tolerated. Do not discontinue Trintellix treatment abruptly. Reduce doses of 15 mg/day or 20 mg/day to 10 mg/day for one week before complete discontinuation.
Zoloft (sertraline) is an FDA (U.S. Food and Drug Administration) approved medication manufactured by Pfizer Inc. It is classed as a selective serotonin reuptake inhibitor (SSRI) used to treat:
Zoloft is available in tablet form, in the following doses: 25 mg, 50 mg, and 100 mg, and as an oral solution, 20 mg/mL. Your recommended starting and maintenance dose will be based on the condition you are being treated for.
The most common side effects of Trintellix in clinical trials include:
More serious side effects of Trintellix include:
The most common side effects of Zoloft in clinical trials compared to placebo include:
More serious side effects of Zoloft include
These aren’t all the side effects Trintellix or Zoloft can cause. You can find more details in the patient leaflet that comes with your medication. If you have any concerns about side effects, talk to your physician or a pharmacist.
Trintellix can interact with other medications. These include:
Zoloft can interact with other medications. These include:
Trintellix and Zoloft can interact with other medications. This can change how Trintellix and Zoloft and other medications work and can make side effects more likely. Tell your prescribing physician about all your drugs, including vitamins and dietary supplements.
You should not use Trintellix if you:
Talk to your doctor before using Trintellix if you:
You should not use Zoloft if you:
Talk to your doctor before using Zoloft if you:
If you have any concerns about Trintellix or Zoloft side effects, talk to your physician, or pharmacist for medical advice. Also inform your healthcare provider about any medical conditions, supplements, and over-the-counter meds you are taking. You are also encouraged to report side effects to the FDA: visit http://www.fda.gov/medwatch or call 1-800-FDA-1088.